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According to Sekhar et al., diabetic patients exhibit erythrocyte glutathione concentrations up to 73.8% lower than those of healthy adults [1]

However, in spite of its ability to trigger MOR regulation, exposure to morphine induced superactivation of the striatal cAMP cascade [69], suggesting that MOR desensitization when associated to this effector might not be enough to completely avoid cellular compensatory mechanisms

Primary and secondary antibodies (Supplementary Table 2) were incubated overnight at 4 o C, followed by 1 h at RT in the dark, respectively

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Various CQD-based systems have shown potential anticancer effects