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Acknowledgements This research was supported by the National Key Research and Development Program of China (grant number (2020YFA0509101)), the National Natural Science Foundation of China (grant numbers 82130107, 82330052, and 82202038), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0940000), the CAS Project for Young Scientists in Basic Research (YSBR-074), the Fundamental Research Funds for the Central Universities, the outstanding Youth Project of Anhui Provincial Natural Science Foundation (2408085Y049), the Research Start-up Funding of the Institute of Health and Medicine, Hefei Comprehensive National Science Center (2024KYQD004), the Natural Science Foundation of Jiangsu Province (BK20221085), and the key project of Anhui Provincial Department of Education Fund (2024AH052060)