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Nature 369 , 488491 (1994)

Initiation and progression of PD is dependent upon cellular events, including failures in the protein degradation machinery, oxidative stress, mitochondrial dysfunction, defects in mitochondrial autophagy (mitophagy) and the continuous accumulation of -synuclein, driven through cell to cell interactions between glial cells and neurons that ultimately lead to apoptosis [7,10,18]

Materials and methods 2.1

Initial underestimations of the total microbial species in the intestine have been documented in various ex vivo and in vivo studies, attributed to challenges in culturing specific microbes [21]

In contrast, 2,3-dimercapto-1-propanesulfonic acid (DMPS), a heavy metal chelator, has the highest affinity for copper