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Transient hypoperfusion and subsequent ischemic events affecting the optic nerve head are the precursors to hypoxia [526]

Fertil Steril 113(3):552-560 e3 Agarwal A, Leisegang K, Majzoub A, Henkel R, Finelli R, Panner Selvam MK et al (2021) Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence

NK cells also make Rho family-dependent ruffles when they attach to target cells, and impaired membrane ruffling severely decreases their cytotoxic activity (77)

After this, NPs must cross the BBB, a highly selective barrier formed by endothelial cells in the brain blood vessels that limits the diffusion of most substances, including therapeutic agents