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Figure 1 Vitamin B12 deficiency, defined as ciculatory B12 level below 150200 pg/mL (borderline 200300 pg/mL) (8), is a significant global health concern, particularly affecting the elderly (9, 10), pregnant women (11), and young children (12), especially in regions with limited dietary options

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New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

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These include both immune-stimulating and immune-suppressing peptides, depending on the therapeutic application