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Similarly, CD39/CD73-mediated adenosine production by CSCs and Tregs generates high extracellular adenosine, suppressing Teff and NK cell function, thereby driving acquired resistance

Furthermore, this effect is dose-dependent

Ann Epidemiol 30:6670

Secondarily, the thiolate oxidizability in most biomolecules is modulated by the adjacent basic groups, since protonation of any such group exerts an electron-withdrawing effect on the thiolate

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