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ALDH2 contains a reactive Cys nucleophile in its active site, which is modified by 4-HNE

10.3389/bjbs.2021.10120 3 AbdelnabyE

163165 AA is the main substrate of both isoforms, but LA is a known competitive substrate and inhibitor of prostaglandin formation by COX-1 and COX-2

It is important to always check the surgeons expertise, the clinics safety protocols, and the results of previous before and afters when making your decision

Calabrese V, Di Maio A, Marino G, Cardinale A, Natale G, De Rosa A, Campanelli F, Mancini M, Napolitano F, Avallone L et al (2020) Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia