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Under conditions of oxidative stress, the GSH/GSSG ratio decreases, indicating an increased demand for glutathione to scavenge ROS
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GSH plays a key role in the regulation and maintenance of intracellular redox status in the brain as well as participating in multiple detoxification functions [52,53]
Treatment options may include medications, physical therapy, injections, or surgery, depending on the underlying cause of the pain
doi: 10.1164/rccm.200711-1749OC
