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Mitochondrial Dysfunction The role of mitochondrial dysfunction in CVS pathophysiology was postulated based on the striking maternal inheritance pattern, the presence of an energy-depletion pattern on urine organic acid measurements and the efficacy of mitochondrial-targeted therapies, such as coenzyme Q10, L-carnitine, and riboflavin (5254)

Polyak SJ, Mac Ardle S, Liu SL, Sullivan DG, Chung M, Hofgartner WT, Carithers RL, Mac Mahon B, Mullins JI, Corey L & Gretch DR (1998) Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection