tingling after b12 injection Most people think they just need more sleep or more coffee… ☕ But these symptoms can actually be signs of low Vitamin B12: • Feeling constantly drained • Numbness or Why do I feel worse

By blocking NNMT, it prevents the enzymatic diversion of nicotinamide away from the NAD+ salvage pathway, preserving intracellular NAD+ levels and SAM availability

Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270272

NNMT : (Vitamin B3, -) NAD (SIRT1-7), PARP, CD38 , , SAM (S-) , , SAM , , , , 5-Amino-1MQ NNMT NAD SAM

This is symptom-driven

Combined nicotinamide N-methyltransferase inhibition and lean-diet substitution reduces body weight and liver fat in obese mice