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Estimation of patient height: Due to the limitations in the ICU, the patients height is calculated based on the following formula [22]: Estimation of patient weight: Due to the limitations in the ICU, the patients weight is calculated based on Chumlea I formula [23]: Blood drawing will be executed at baseline and end of the trial

Metabolite levels and depressive symptom scales were expressed as SD unit increase to derive standardized estimates

Typically, bacteriostatic water is used, and the volume can range from 1mL to 10mL depending on the specific requirements

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The clinical data in this regard is still very limited and needs expanding through randomized, placebo-controlled studies to draw final conclusions on whether polyphenols may be a class of clinically effective nutraceuticals in patients with CFS