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In this context, Persinal-Medina and collaborators developed a polymerizable skin hydrogel composed of trapped keratinocytes and fibroblasts within a fibrin structure to improve the treatment of skin wounds (Persinal-Medina et al., 2022)

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HA functioned not only as a delivery vehicle but also as an immunomodulatory agent, binding to CD44 receptors on immune cells such as macrophages, thereby suppressing their activation through TLR2/4 pathway modulation and reducing pro-inflammatory cytokine production

Endoscopic management of early adenocarcinoma and squamous cell carcinoma of the esophagus: screening, diagnosis, and therapy