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In addition, subclinical intestinal inflammation has been observed in treatment nave patients with early RA as well as before the onset and during the course of arthritis in animal models, and there is evidence about an impact of inflammatory cytokines (such as tumor necrosis factor (TNF) and interferon gamma (IFN)) on the integrity of TJs by reducing the levels of occludins and ZO-1 [2, 5]

The preferred route for administration of glutathione GSH without having to resort to injection, is absorption from the orobuccal mucosa

However, their efficacy in vivo models has not been reported yet

Tentori, L