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The 2.4 mg maintenance dose sits on the shoulder of the effect curve rather than at a hard ceiling, which is why higher investigational doses still add weight loss
A.MithenR.BennettM.JefferyE
On the other hand, overexpression of CDK4, CDK6 or cyclin E1 are associated with resistance of tumors to CDK4/6-inhibitors (discussed further below)
8f, i, j, Supplementary Fig
[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Ly J., Lagman M., Saing T., Singh M.K., Tudela E.V., Morris D., Anderson J., Daliva J., Ochoa C., Patel N., et al
