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These effects are correlated with a decreased astroglial reactivity and production of pro-inflammatory proteins, since ACEA did not impair A aggregation ( Similarly, CBD and THC have demonstrated neuroprotection in chronically treated APP/PS1 mice showing improvements in memory tasks and a decrease in soluble A42 levels, astrogliosis, and several neuroinflammation markers (Cheng D
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Pharmacol Ther.2005;106(3):357387
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