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Some medical conditions like individuals with gastrointestinal disorders such as Crohns disease, and celiac disease, or those who have undergone gastric bypass surgery may also be at risk of developing vitamin B12 deficiency due to impaired absorption

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The 2024 NICE Guideline NG239 from the United Kingdoms National Institute for Health and Care Excellence similarly distinguishes between patients who can be managed with oral therapy and those who require intramuscular treatment