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Purification, characterization, and localization of a novel trypsin-like protease found in the human airway

Upon increasing pathologies, such as neuroinflammation, synapse loss and amyloid plaque accumulation, the brain shifted to a state of hypometabolism [142]

Central to this concept linking neural and systemic functions is the concept of allostasis (adaptation) and allostatic load/overload (pathophysiology) [6] that emphasizes the role of endogenous mediators for adaptation in contributing to pathologies, including MDD, when activated persistently or dysregulated under circumstances of toxic stress and health-damaging behaviors (poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption)

doi:10.1038/nature09922

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