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A suitable experimental model that simulates the physiology of the human heart is needed
ATF4 siRNA produced a 50% decrease in ATF4 mRNA that was sufficient to blunt but not block the MR-induced increases of some ATF4 target genes (e.g., ASNS, CHAC1, DDIT4, FGF21), while fully inhibiting MR-induced increases of other ATF4 target genes (e.g., CARS, MARS, EIF4EBP1, PSAT1, and SESN2) (Fig
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Epub 2011 Oct 20 DOKIC, I., et al
