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These alterations create a vicious cycle of mitochondrial dysfunction, oxidative injury, and myofiber apoptosis, ultimately leading to irreversible supraspinatus atrophy and impaired regeneration after rotator cuff tears

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The Ni-NTA resin was packed into a glass column and washed with 25 column volumes of 20 mM HEPES pH 7.4, 100 mM NaCl, 2 mM MgCl 2 , 0.01% (w/v) LMNG and 0.0006% (w/v) CHS, 1 M peptide, followed by elution using the same buffer supplemented with 250 mM imidazole and 3 mM CaCl 2

Ganzella M, Jardim FM, Boeck CR, Vendite D (2006) Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice

Converted to active calcitriol, it regulates calcium and phosphate