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Relapse is driven by Tumor Initiating Cells (TICs), a subset of tumor cells capable of regrowing the tumor and highly resistant to therapy
During insulin therapy, iron uptake can be increased by increasing the transferrin receptor 1 (TfR1) in adipocytes (72)
Abraham CR, Li A
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities
Think of it like this: if you cover a garden sprinkler for a few hours, when you uncover it, all that built-up pressure makes it spray harder for the next 1824 hours
