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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway Science 2001 293 : 14951499 Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M

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indicates that vitamin B3, specifically niacinamide riboside, may enhance muscle mitochondrial function and modulate gut microbiome composition in humans (51)

In chronic pain patients with RLS, vitamin D3 deficiency correlates with higher pain and lower quality of life [77]

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