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Notably, the combination of JHU083 plus anti-PD1 or JHU083 plus anti-PD1 plus anti-CTLA4 resulted in greater inhibition of tumor growth and enhanced survival, suggesting an additive effect of combining metabolic therapy with checkpoint blockade (Supplemental Figure 6, A and B)

Mol Pharmacol 65(5):12381247 Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA et al (2009) Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells

There were no discernible mortality difference between the male and female flies (Katzenberger et al., 2013)

Riou A, Broeglin A, Papassotiropoulos A, Eckert A, Grimm A

Studies indicate that vibration stress induces biochemical changes, leading to elevated concentrations of brain neurotransmitters (Ariizumi et al., 1986