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Triggering innate and adaptive responses To stimulate adaptive immunity, a vaccine requires a pathogen-specific immunogen as well as an adjuvant the latter stimulates the innate immune system and provides the necessary second signal for T cell activation

MPTP for Parkinsons disease has been known since 1982 [224]

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When the body has increased homocysteine, it can disrupt cognitive ability and affect mood leading to depressive symptoms [5]

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