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The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies

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Symptoms Nausea Jaundice Pain in abdomen vomiting Gray- or clay-colored stools Loss of appetite Joint pain Fatigue Dark yellow urine Fever Diagnosis When diagnosing hepatitis C, healthcare providers follow a comprehensive approach

Homocysteine is an amino acid your body makes from Methione (which has to be ingested being one of the essential amino acids our bodies need to get from our diet)