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References 1.Ludwig J, Viggiano TR, McGill DB, Oh BJ

Fahn S., Oakes D., Shoulson I., et al., Levodopa and the Progression of Parkinson's Disease, New England Journal of Medicine 351, no

If your medication has a warning not to eat grapefruit while taking it, you shouldnt take berberine with it, either.55 (Note, also, that berberine isnt the only supplement that interacts with cytochrome P450)

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Notably, the clinical phase III trial testing the therapeutic effect of Bardoxolone methyl, a potent Nrf2 activator, on chronic renal disease associated with type 2 diabetes was terminated because of an increased rate of cardiovascular events, including heart failure and deaths (Ouyang et al., 2014