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The results showed that loss of GSTA4 significantly decreased cell proliferation and clonogenicity, whereas it increased intracellular reactive oxygen species and cell susceptibility to 5-fluorouracil (5-FU) and oxaliplatin

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However this gel is resistant against enzymatic attacks and does not absorb biomolecules, thus it is used widely despite its mechanic disadvantages [8,14]

These overexpressing cells had decreased oxidative modification of mitochondrial DNA and enhanced resistance to oxidant-induced cell death (215, 256)