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This is in contrast to the postpubertal stage, where the reduced ER levels prevent the ER/IRS1 complex formation, and alter the signaling via the Raf/MAPK pathway [110]

[DOI] [PMC free article] [PubMed] [Google Scholar] Umoh, I

indicated that flupirtine, a clinically available analgesic activating slow axonal K + channels in the A-fibers of peripheral nerve, alleviated the acute OIPN by suppressing axonal hyperexcitability (Sittl et al., 2010)
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10.1111/j.1469-8749.1997.tb07500.x 7