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Another mechanism, which is a problem in treatment, is gene rearrangement

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Expression of Mcl-1 is upregulated in many cancers, and it was seen to be upregulated as a resistance factor to chemotherapies, Keating says
[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Ganguli M, Snitz BE, Saxton JA, Chang CC, Lee CW, Vander Bilt J, Hughes TF, Loewenstein DA, Unverzagt FW, Petersen RC

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