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Also, the cyclic AMP-protein kinase signaling pathway that influences the expression and function of nuclear transcription factors such as c-fos, p53, AP-1, Sp1, and CREB (Ca2 + /cAMP response element-binding protein) involved in the transition from proliferation to differentiation of neural cells is impaired by organophosphates (Costa et al., 2008)

In the early stages of tumor development, some authors consider this phenomenon positive

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