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(A) Diagrammatic representation of the construct ( pbggcs-comp ) used for complementation (top), the dssurrna genomic locus used for targeted integration of the construct (center), and the locus after integration of the construct by single cross-over recombination (bottom)

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The detrimental effects of ROS on cartilage homeostasis can be effectively alleviated by augmenting cellular antioxidant activity under stress conditions, and several attempts have been made to treat OA by targeting the regulators involved in oxidative stress production in cartilage 84,85,86