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In addition, compared with that of the control (nave) group, the mRNA level of COLXA1 , a marker of hypertrophic chondrocytes, was significantly increased in GSH-low hES-MSCs but was decreased in GSH-high hES-MSCs (Fig

Therefore, early intervention in replenishing mGSH stores by supplying GSH precursor such as N -acetylcysteine (NAC) or targeting upstream mechanisms involved in mitochondrial dysfunction and ROS generation, such as the sustained activation of c-Jun N-terminal kinases (JNK), can result in the protection of APAP-mediated hepatotoxicity

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