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The ODT formulation may produce slightly less dramatic results due to lower bioavailability, though individual responses vary considerably

Arancibia S, Lecomte A, Silhol M, Aliaga E, Tapia-Arancibia L (2007) In vivo brain-derived neurotrophic factor release and tyrosine kinase B receptor expression in the supraoptic nucleus after osmotic stress stimulus in rats

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In these assays, CuCl 2 alone showed no activity up to 250 M, whereas Cu 3 -TC-Py consistently produced IC 50 values in the 10-30 M range and Cu 3 -TC-Thio in the 30-60 M range
