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Conclusion In summary, there is a strong link between gut microbiota and PND that depends on the gut-brain axis

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In the further studies, we noted that many other herbal medicines ( Coptis chinensis Franch , Phellodendron amurense , and Berberis sargentiana Schneid , et al.) also reportedly contain some of the same alkaloids compared with FRP (Wang et al., 2009