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Description
These changes in expression may be due to decreased glutathione and increased oxidative stress

The isocitrate dehydrogenase reaction is the rate-limiting step, as well as the first NADH-yielding reaction of the TCA cycle

Watch for early warning signs such as: Dark-colored urine Dry mouth Fatigue Muscle cramps Headache Feeling lightheaded or dizzy Reduced performance during work or exercise The best way to stay ahead of dehydration is to drink fluids consistently throughout the day, replace electrolytes during prolonged sweating, take breaks in the shade or air conditioning, and recognize when symptoms require medical attention

doi: 10.1111/and.13898

Cancers (Basel) 15, 1061
