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Peroxisomal CAT reversibly transforms both endogenous (derived from peroxisomal fatty acid -oxidation) and supplemented acetylcarnitine into acetyl-CoA

ROS trigger apoptosis by activating the pro-apoptotic proteins caspase-3/7/9 and cleaved PARP, disrupting mitochondrial function, and in pancreatic cancer melatonin-induced ROS enhance apoptosis through the mitochondrial pathway (Florido et al., 2022b)

Introduction Vitamin B 12 (B 12 ) is an essential cofactor for two enzymes in human metabolism: methylmalonyl-CoA mutase (catalyzing the conversion of methylmalonyl-CoA to succinyl-CoA), and methionine synthase (catalyzing the synthesis of methionine from homocysteine)

Reference: Reynolds L, Park M, Kim RA, et al

Xue M, Joo YA, Li ST, Niu C, Chen G, Yi XC, et al
