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High NNMT levels (which naturally happen as we age) can become a problem

Mast Cells Participate in Chronic Low-Grade Inflammation within Adipose Tissue. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, vol
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Nature 515, 279282

When NNMT is inhibited by compounds like 5-Amino-1MQ, more nicotinamide becomes available for conversion to NAD+ via NAMPT
