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The systematic analysis found that cartilage lesions complicated by limited progenitor cell activity and healing capacity, large size, high mechanical demands, local and systemic inflammation, or other systemic diseases are often excluded from treatment, likely due to complications and poor outcomes after cartilage restoration procedures in this context

Since Provenge (sipuleucel-T) was approved by the FDA as the first cancer vaccine for prostate cancer, peptide vaccine therapy has been widely used for other cancers, including gastric, colorectal, and pancreatic [162]

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