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J Mol Cell Cardiol 2005

SW and JNR designed the overall experiments and analyzed data

The skin-brightening effects of this plant are attributed to calycosin, a polysaccharide that has been demonstrated to reduce the activity of tyrosinase, melanogenesis proteins, and MITF, which are involved in melanin formation

In Fabry disease, mutations in the GLA gene destabilize -galactosidase A, leading to misfolding, ER retention, and degradation via ER-associated pathways, thereby preventing lysosomal trafficking and resulting in glycosphingolipid accumulation and multiorgan dysfunction

Targeting pathways including NCOA4 may be a promising approach for the treatment of glioma