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It also plays an essential role in folate and related one-carbon metabolism, where FAD is required as a cofactor for methylenetetrahydrofolate reductase (MTHFR), a key folate-metabolizing enzyme

Oxidative stress is one of the leading causes of most neurodegenerative disorders [31, 32]

In recent years, significant advancements have transformed the therapeutic landscape with the introduction of gene therapy, stem cell therapy, targeted therapy, and immunotherapy modalities that enable more precise and personalized cancer management [7]

Funding Statement This research was funded by a large research grant from statutory funding for young researchersdoctoral students for 2021, grant number 502-14-33064130-45019