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Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction

For instance, pH-sensitive systems exploit the acidic milieu of inflamed or ischemic brain regions (pH 6.56.8) and endolysosomal compartments (pH 4.56.0) to trigger disassembly of polymeric micelles, liposomes, or dendrimer hybrids loaded with curcumin, resveratrol, or withanolides

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Genetic analysis is needed to clearly distinguish these disorders