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It is important to note that curcumin exhibits a biphasic dose-response relationship: lower doses activate protective pathwaysincluding increased total glutathione (GSx) and GST activitywhile higher doses deplete GSH, reduce related metabolites (e.g., taurine, homocysteine), and may induce pro-oxidant effects or cellular toxicity (Scharstuhl et al., 2009)

The GHGHR interaction can activate both STAT5 and ERK dependent intracellular signalling pathways

( Feed analysis The DM of the diet was determined by oven drying at 103C to harvest the constant weight ( N by 6.25, and the total N content was determined by using the Kjeldahl method (ISO 5983-1, I) ( Statistics All the data were statistically analyzed with IBM SPSS statistics version 22.0 (SPSS Inc., Chicago, USA)

Neutrophil counts peak on the day of parturition as cows are under nutritional, endocrine, and physiological stress (47)

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