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Second, aNDBs consist of positively charged molecules (chondroitin sulfate, o-pullulan, alginate, -polylysine, chitosan, magainin-2, etc.), containing cationic groups such as quaternary ammonium, quaternary phosphonium, guanidinium, or tertiary sulfonium (Santos et al., 2016), which have a positive charge

111,112,113,114 The field of osteochondral tissue engineering has matured substantially and progress towards clinically applicable replacements will be vital for the large portion of the population currently excluded from clinical trials

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