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A number of pathologic conditions, including IBD, disrupt ER function, resulting in ER stress [98]

The free radical theory of aging proposes that the damage from oxidative stress plays a key role in age-related diseases ( Magnetic resonance spectroscopy (MRS) studies show that older individuals have lower GSH levels in the posterior cingulate and occipital cortices ( Some studies in older adults addressed the relationship between GSH levels and general cognitive integrity and found a null association between cognitive integrity and GSH levels in the cingulate, occipital, medial frontal, and sensorimotor cortices ( Whereas the above-mentioned studies have addressed the relationship of cognitive integrity with baseline levels of GSH, to our knowledge, it has not been explored whether GSH is modulated (showing a decrease or increase) as a consequence of cognitive effort (active engagement in a cognitive process) or sustained cognitive effort (continued engagement during a prolonged period)

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Parkinsons disease PD is the second most common neurocognitive and chronic neurodegenerative disorder affecting the nervous system and body parts controlled by the nerves of the nigrostriatal pathway

While it does not directly stimulate collagen creation (like vitamin C or retinoids do), its cleansing and antioxidant effects assist the skin in maintaining a healthy environment