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At high concentrations of ATP, the inhibitor site becomes occupied shifting the equilibrium of PFK-1 conformation to that of the T state decreasing the ability of PFK-1 to bind F6P

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F., The Therapeutic Potential of Monoamine Oxidase Inhibitors, Nature Reviews Neuroscience 7, no
Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis