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Cooperation with other antitumour therapies Radiotherapy Although there is some controversy regarding the survival benefit of this technique, radiation therapy has been used to treat borderline resectable PDAC, providing the possibility of resection [262]
Copper storage and transportation After uptake by the intestinal epithelial cells, copper is transported and exported into the bloodstream by the ATPase copper transporter 7 A (ATP7A) [18]
The Atx-binding site on human PDI is located on an extensive area on its interfacial binding surface between domains b and b like the known binding sites of endogenous PLA2 such as the mammalian GIB, GIIA, GV, and GX PLA2s ( MT-CO2 gene ( Crotamine, a PLA2 with positively-charged 42 amino acids, 2+ from the endoplasmic reticulum (ER) and lysosomes, m depolarization, and in vivo , it induces selective penetration in proliferating cancer cells and consequently, apoptosis without toxic effect on non-tumoral tissues ( 2+ uptake by mitochondrial calcium uniporter and mPTP opening ( 2+ transfer is essential for cancer cell bioenergetics ( 2+ -dependent cytosolic proteases
R., Ortega M
when ROS accumulate, they can be released from Nrf2 bound to KEAP1 by an oxidative reaction to increase antioxidant capacity [124, 125]
