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556 In a phase I study (NCT05077501), the novel Trk receptor PAM ACD856 ( 58 )

Addressing the mechanism of the H 2 O 2 -induced macrophage death, immunoblotting for cleaved caspase-3, measurement of released IL-1 and IL-18, and use of nercostatin-1 did not support caspase-3-dependent apoptosis, inflammasome activation or necroptosis as the underlying cause of the cytotoxicity, respectively
Primaquine revisited six decades after its discovery
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