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However, the ligand-binding pocket exhibited two unique structural features that were not observed in previously determined GPCRs

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Autooxidation produces a succession of bicylopentadione compounds, where the seven-carbon chain is oxygenated and doubly cyclized (74), hence yielding bicyclopentadione, vinyl ether, and spiro epoxide (74, 92)

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Finally, chondrocytes of the hypertrophic zone participate in mineralization of cartilage and, most importantly, determine bone length