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Research data suggest that NAC requires multiple doses to achieve efficacy in oxaliplatin-induced CIPN

Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 16,17,18

Enzyme-based micro/nanomotors are among the most prevalent chemical fuel powered motors, which rely on the highly efficient biocatalytic processes of intrinsic biofuels in natural biological hosts to produce a robust propelling force that surpasses random Brownian motion for effective autonomous motion 27,28

[DOI] [PubMed] [Google Scholar] 2.Hamed K, Alosaimi MN, Ali BA, Alghamdi A, Alkhashi T, Alkhaldi SS, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] [199].Sheldon AL, Robinson MB, The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention, Neurochem