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Discontinuation due to side effects ran at 7% in Phase 2 data, which is lower than Semaglutides 11% discontinuation rate despite Semaglutide having a higher reported nausea incidence at 44%
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In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation

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Covid-19 prompted the British Society of Haematology to issue pandemic B12 guidance and this outlines some of the principles for moving to oral B12 preparations
