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The Diversity in Physiological Functions of Free Glutamine and Glutamate In the last decade, it has been recognized that glutamine and glutamate are essential AAs at key times in life, including the neonatal period when rapid growth occurs (78, 79)

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These channels define the pore pathway 47 (Box 1) and are exemplified by claudin-2, which mediates paracellular flux of small cations, such as Na + , and water 42,43,48,49